INSTANUTE DR

• Simple formulation operations , usage and “scale up”;
• Ideal features for delayed release;
• Quick reconstitution in water (reduction of process times and consequent cost savings);
• Secure Usage as reconstitution does not require the use of solvents;

Reconstitution level:
Reconstitution in purified water up to 12% w/w of solid

Recommended equipment:
Mechanical stirrer with variable speed
Mixing Vessel

Calculation for the quantities of INSTANUTE DR and solvent:
The amount of INSTANUTE DR (12% w/w) and water required is based on the amount of cores that need to be coated and the desired weight gain. For 1 kg of tablets and a weight gain of 10%, 100 g of INSTANUTE DR will be required to be added to 833 g of water maintained under stirring.

Reconstitution process:

• Add the weighed amount of water to a mixing vessel;
• Using a mechanical mixer, mix the water to form a vortex;
• Add the weighted quantity of INSTANUTE DR at the center of the vortex with constant speed, avoiding the formation of granules and maintaining a vortex throughout the addition process. After adding the full amount of INSTANUTE DR, reduce the mixing speed to eliminate the vortex. Continue mixing for 45 minutes.