INSTANUTE MB

Description:
INSTANUTE MB is a water-reconstituting gastro-soluble coating system designed to be used for moisture sensitive nutritional and food products. It is available in a wide range of colors, both of natural and synthetic origin, and can also include flavors.

A special formulation, which combines hydrophobic plasticizer and insoluble diluent, allows to form a moisture barrier, protecting the core from degradation.

Benefits:

Coating system widely accepted from a regulatory, development and manufacturing point of view;
Minimal impact on dissolution and disintegration;
Greater stability and protection from physical damage;
Low MVTR (Moisture Vapor Transfer Rate) which provides good protection for moisture sensitive substrates.

Reconstitution level:
Reconstitution in purified water up to 12% w/w of solid

Recommended equipment:
Mechanical stirrer with variable speed
Mixing Vessel

Calculation for the quantities of INSTANUTE MB and solvent:
The amount of INSTANUTE MB (12% w/w) and water required is based on the amount of cores that need to be coated and the desired weight gain. For 1 kg of tablets and a 3% weight gain, 30 g of INSTANUTE MB will be required to be added to 250 g of water maintained under stirring.

Reconstitution process:

Add the weighed amount of water to a mixing vessel;
Using a mechanical stirrer, mix the water to create a vortex;
Add the weighed quantity of INSTANUTE MB to the center of the vortex with constant speed, avoiding the formation of lumps and maintaining a vortex throughout the addition process. After adding the full amount of INSTANUTE MB, reduce the agitator speed in order to eliminate the vortex. Continue mixing for 45 minutes.

INSTANUTE MB

INFORMAZIONI